Injectable hydrogel provides growth-permissive environment for human nucleus pulposus cells
نویسندگان
چکیده
منابع مشابه
Injectable laminin-functionalized hydrogel for nucleus pulposus regeneration.
Cell delivery to the pathological intervertebral disc (IVD) has significant therapeutic potential for enhancing IVD regeneration. The development of injectable biomaterials that retain delivered cells, promote cell survival, and maintain or promote an NP cell phenotype in vivo remains a significant challenge. Previous studies have demonstrated NP cell - laminin interactions in the nucleus pulpo...
متن کاملNovel Hydrogel for the Replacement of the Nucleus Pulposus
INTRODUCTION Back pain induced by the degeneration of the hydrogel core of the intervertebral disc, the nucleus pulposus (NP) surrounded by the annulus fibrosus (AF), is currently a major public health issue. Different treating approaches exist such as vertebral fusion and total disc replacement with for example a SB Charité Prosthesis. However, recent trends in surgery are shifting towards pre...
متن کاملAcid-sensing ion channel 1a regulates the survival of nucleus pulposus cells in the acidic environment of degenerated intervertebral discs
Objective(s): Activation of acid-sensing ion channel 1a (ASIC1a) is responsible for tissue injury caused by acidosis in nervous systems. But its physiological and pathological roles in nucleus pulposus cells (NPCs) are unclear. The aim of this study is to investigate whether ASIC1a regulates the survival of NPCs in the acidic environment of degenerated discs. Materials and Methods: NPCs were i...
متن کاملAn injectable nucleus pulposus cell-modified decellularized scaffold: biocompatible material for prevention of disc degeneration
We developed a nucleus pulposus cell (NPC)-modulated decellularized small intestinal submucosa (SIS) scaffold, and assessed the ability of this material to prevent Intervertebral disc degeneration (IVD) degeneration. Decellularized porcine SIS was squashed into particles and the biological safety and efficiency of these particles were evaluated. Next, SIS particles were seeded with rabbit NPCs,...
متن کاملCreation of an injectable in situ gelling native extracellular matrix for nucleus pulposus tissue engineering.
BACKGROUND CONTEXT Disc degeneration is the leading cause of low back pain and is often characterized by a loss of disc height, resulting from cleavage of chondroitin sulfate proteoglycans (CSPGs) present in the nucleus pulposus. Intact CSPGs are critical to water retention and maintenance of the nucleus osmotic pressure. Decellularization of healthy nucleus pulposus tissue has the potential to...
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ژورنال
عنوان ژورنال: Journal of Biomedical Materials Research Part A
سال: 2015
ISSN: 1549-3296
DOI: 10.1002/jbm.a.35580